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Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. SDS - Safety Data Sheet. Product Name: Microcrystalline Cellulose E460 1.2. II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. In extrusion-spheronisation, it is the excipient of choice. : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous
Materials Information System (WHMIS) requirements. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. cas:9032-51-3 msds CELLULOSE PAB. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. SDS. Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. <> The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. Synergies to simplify formulation challenges and reduce operational costs. Avicel RC-591 & CL-611 - Description. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. Product Name: Microcrystalline Cellulose 1.2. Wu, K. Zuurman, H.W. %
1.3. Gloves, eye protection and a dust mask should be used. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. Are you looking for information about products and services by region? Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. Watch Now. 5 0 obj
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We can send by Fedex, by ship or by plane according to international rules. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. >>
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In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. Microcrystalline Cellulose (MCC) MSDS 1. We are artists at heart and creators by nature. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . EMCOCEL 90 M. 130. The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. A family of polysaccharide products that allow distinctive drug delivery solutions. MSDS Ref. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Avicel Microcrystalline Cellulose: Chemical Identifiers. B;vLZpHU%ChUyD+[ Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Cellulose microcrystalline for column chromatography. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. 6 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O 1.3. It is a white, free-flowing powder. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). Chemical Formula: (C6H10O5)n 1.4. It is, however, a good source of fibre. CAS #: 9004-34-6 gac74
[#B6`Wnw7 on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. /Contents 4 0 R
The figure below illustrates the structural organisation of cellulose within plants. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . Microcrystalline Cellulose / Avicel PH-102. pH 6.0 to 8.0 . METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Thus, Avicel contributes no or very few calories to the food system. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . <>
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It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. EMCOCEL XLM 90. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. Avicel PC 611 Microcrystalline Cellulose. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. It is also inert and biocompatible. All Rights Reserved. <>
Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. Material safety data sheet - FMC Corporation. All rights reserved. Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine 9,LL!z An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Find answers in our support articles. 130. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. Eur., JPE . MATERIAL SAFETY DATA SHEET Version: 1.0 1. There have always been two different points of view for the liquidity of MCC. However, if handling bulk powders, observance of appropriate safeguards is recommended. Battista, O. However, it yields non-digestible fibre. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Microcrystalline Cellulose E460 MSDS 1. No. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. <<
Product and Company Identification . ). Browse Avicel PH-101 and related products at MilliporeSigma. All Rights Reserved. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. Request media, explore upcoming events and read our latest updates. Validity Area. PDF (2.77 mb) 2021 FMC Sustainability Report. : 51395-75-6 Date Approved: 01/31/2008 Revision No. endobj
Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. Truly distinctive drug delivery solutions. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . Millipore. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. cas:9000-11-7 msds Carboxymethyl cellulose. Magazine: Material safety data sheet - FMC Corporation. Quantity: 1 700 kgs. EINECS #: 232-674-9 1.7. MSDS Ref. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. Molecular weight: Not Applicable 1.5. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Avicel PH-200 microcrystalline cellulose NF, Ph. Report Category. Alginates also function as actives in some anti-reflux products. . By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. SUBSTANCE IDENTIFICATION 1.1. HMo@9, U Q!R/1*;` Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . lH5JWy}DgKRR"Fs <<
To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . SCMm_>x^O9l (n. X\o^ These, in turn, are assembled into fibrils in the cell wall. Catalog Number 102331. Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. endstream
It works as a moisture sponge and permits the controlled growth of spheroids. Page 1 of 8. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. Revision No. Combines good flow and high compactibility. G2W4de=u183KGH{ vQ#4:1\wc In 1964 FMC, Corporation . The 'Substance identity' section is calculated from substance identification information from all ECHA databases. FMC, JRS and Mingtai were estimated to hold for . Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. q9;v80 Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Learn about FMC's differentiated biologically-based crop solutions. Molecular Weight null. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q
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U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. Chemical Formula: (C6H10O5)n 1.4. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e
^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w
'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . 0.25 - 0.37. Delivering efficient and robust formulations. Microcrystalline Cellulose Side Effects. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. The typical mean particle size is 20200 m. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W CAS 9004-34-6, pH 5 - 7.5. "l%I-*j|-)@
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?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. Have an order or account question, find answers in our Online Support articles. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . Hi, let us know if you have any questions as you visit our website. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. Fiber supplements can lessen the absorption of some . This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. PDF (28.38 mb) 2022 Corporate Fact Sheet. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. Synonyms: Cellulose, Cellulose powder, Cotton linters. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. By producing Avicel . Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. Production of Pharmaceutical Grade Microcrystalline Cellulose. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. . Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.