One or both of the factor V genes can be mutated and cause the altered form of the factor V protein known as the Factor V Leiden protein to be made. As a result, factor V works in overdrive, making your blood more likely to clot when it shouldnt. Soybean oil or soybean milk, as well as liver, has high vitamin K content, which may interfere with the action of VKAs. But if you do, prompt treatment can manage your condition. Lean protein: Prioritize lean proteins such as chicken, turkey and lean beef. Read below where Experts have answered questions about Factor V Leiden. It depends on the specific details of the previous deep vein thrombosis or pulmonary embolism. while also discussing the various products Sartorius produces in order to aid in this. Factor V Leiden: Care Instructions - Alberta Factor V Leiden and prothrombin gene mutations cause about 50% of inherited coagulopathies. Since factor V Leiden is a risk for developing blood clots in the leg or lungs, the first indication that you have the disorder may be the development of an abnormal blood clot. Drink plenty of fluids (without alcohol). 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, (https://pubmed.ncbi.nlm.nih.gov/31577252/), (https://www.stoptheclot.org/factor-v-leiden/). Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Factor V Leiden is the name of one such blood clotting disorder. What are the chances of passing down the genetic mutation to my children? Factor V Leiden causes hypercoagulability, which makes it harder for your blood clots to break up. Factor V Leiden may lead to deep vein thrombosis or a pulmonary embolism, which are serious medical emergencies. Have had clots two or more different times in the past. . If you develop a deep vein thrombosis or pulmonary embolism, your provider will prescribe an anticoagulant. Factor V and other proteins work together to help your blood clot when necessary. These conditions can be life-threatening and require immediate medical treatment. Regular noncontact exercise, such as walking or swimming, is still recommended for good health. What will a positive or negative result tell me? If you inherited 2 Factor V Leiden genes, you have the homozygous type of Factor V Leiden. We do not endorse non-Cleveland Clinic products or services. Its the most common blood clotting disorder thats inherited, or passed down within biological families. Enjoy a variety of foods from the 4 food groups. Philadelphia, PA 19182-5687. Pruthi RK (expert opinion). If you have the disorder, you may never develop a blood clot. Is this an emergency? Take frequent breaks during long car rides to get out and stretch your legs. When anticoagulants are prescribed, a prothrombin time (PT) test is used to evaluate its effectiveness. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Avoid smoking, vaping and tobacco use. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Factor V Leiden is also known under its other name Factor V Leiden Thrombophilia. 2018;43 (5) (Specialty&Oncology suppl):12-15. Youre might be wondering, Will this happen to me? Deep venous thrombosis (DVT). Do I need to take medication to prevent additional blood clots? If youve been diagnosed with DVT or a PE, youll have frequent follow-up appointments so your provider can check treatment progress. Cleveland Clinic is a non-profit academic medical center. You may not need to do anything other than lead a healthy lifestyle to minimize the risk of a deep vein thrombosis or pulmonary embolism. Try to build up to 150 minutes of moderate-intensity. Foods high in saturated fat, including animal and dairy fat, coconut oil, palm oil and processed meat. Factor V Leiden is an inherited blood clotting disorder that raises your risk of deep vein thrombosis or a pulmonary embolism. We use cookies to enhance your experience. But because there are many risk factors associated with the development of those pregnancy complications, theres still debate and uncertainty as to how much the factor V Leiden mutation is a cause or just another contributing factor to those pregnancy complications. 2. As they come, write them down. Other things can add to your blood clot risk, including: Youll need a specific blood test to check for the prothrombin gene mutation. For those who are watching their cholesterol, there have been some studies that show low GI diets are helpful at lowering cholesterol levels. You have 1 Factor V Leiden gene from one parent and 1 normal Factor V gene from your other parent. Mayo Clinic is a not-for-profit organization. New York, N.Y.: McGraw-Hill Education; 2016. https://accessmedicine.mhmedical.com. The two most common hematological diseases the impairment of Factor V causes are Factor V deficiency or Owren's disease, and Factor V Leiden. This test looks at how quickly the blood clots. You should know the warning signs of a problematic blood clot so you can identify it and get help. The two most common hereditary thrombophilia conditions are the factor V Leiden and prothrombin 20210 gene mutations, both of which have been the subject of previous Cardiology Patient Pages. on this website is designed to support, not to replace the relationship 4. Zoppi, Lois. Factor V Leiden - Symptoms and causes - Mayo Clinic Yes, those living with factor v Leiden should avoid any foods that contain a high level of vitamin K. (Green leafy vegetables are a big one). Tips on transitioning to a whole food fertility diet. 0000000016 00000 n All rights reserved. Hereditary thrombophilia. Clotting Disorders. The Factor V Leiden protein is harder to turn off than the normal Factor V protein. News-Medical. This content does not have an English version. If you have factor V Leiden, you inherited either one copy or, rarely, two copies of the defective gene. Stand up and walk around during long flights. advice, care, or treatment. Fruits and vegetables: Get at least five servings of fruits and veggies throughout the day, and incorporate all different kinds. In situations where there is a greater chance of clotting (such as surgery, a leg cast, a serious illness or pregnancy) you may be treated with blood thinners until the risk has passed. Heterozygous Factor V Leiden If you inherited one Factor V Leiden gene from one parent, you have the heterozygous type of Factor V Leiden. Blood clots can cause serious problems in your body when they block blood flow, keeping oxygen from getting to your cells. Cranberry juice and other cranberry products can alter the effects of anticoagulants. Accessed June 4, 2018. Clots can form in the veins near your bones that carry a lot of blood (deep veins), a condition called deep vein thrombosis. This is caused by a change (mutation) in the gene for this protein. What can I do to help prevent blood clots from forming? The risks of food-drug interactions include preventing the proper working of a medication, causing unwanted side effects, and changing the way the body uses ingested food or beverages while on the medication. Going on a long flight or a very long road trip. 1-ranked heart program in the United States. If I have children, do they need to be tested? Deficiencies of antithrombin and proteins C/S, elevated fibrinogen levels, and other clotting disorders also raise risk. 0000003776 00000 n The plan depends on exercise as much as diet. Factor V Leiden (pronounced FAK-ter five LYE-den) is a blood clotting disorder that raises your risk of abnormal blood clots. This site complies with the HONcode standard for trustworthy health information: verify here. Because factor V Leiden is a blood clotting condition, you need to have a discussion with your health care team about your dietary restrictions if you are on a blood-thinning medication like warfarin. If you notice any of these problems, call your doctor right away. Lockwood CJ, et al. Talk with your doctor about the risks and benefits of taking these medications. It is not a disease. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017. 0000008077 00000 n This field is for validation purposes and should be left unchanged. The Association Between MTHFR C677T Gene Polymorphism and Repeated People who have inherited factor V Leiden from only one parent have a 5 percent chance of developing an abnormal blood clot by age 65. In this interview, AZoM speaks to Rohan Thakur, the President of Life Science Mass Spectrometry at Bruker, about what the opportunities of the market are and how Bruker is planning on rising to the challenge. Your provider will advise you on whether you need testing, as well as on the pros and cons of testing. Gluten-free: The breads Pasternak allows are flour-free. News-Medical, viewed 04 March 2023, https://www.news-medical.net/health/Anticoagulant-Food-Drug-Interactions.aspx. https://www.uptodate.com/contents/search. The Meat Effect: Protein, Carbs, and Your Diet. For factor V Leiden, some basic questions to ask your doctor include: If your doctor recommends genetic testing, some questions you might want to ask the genetic specialist include: Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. 0000022790 00000 n By continuing to browse this site you agree to our use of cookies. Effective measures to eliminate or reduce other risk factors for DVT or PE, such as smoking cessation, weight loss and having a more active lifestyle. small children have a risk of 1 in 100,000 per year, those in their twenties have a risk of 1 in 10,000 per year, by age 40, this risk is 1 in 1,000 per year. The latest information about heart & vascular disorders, treatments, tests and prevention from the No. Leg wraps that inflate and deflate to keep blood moving in your legs. you have a medical emergency, call 911 immediately. Prothrombin Gene Mutation (Factor II) - Cleveland Clinic It is advised that vitamin K intake through diet (chiefly through liver meats, high amounts of green leafy vegetables, and cranberry juice) also be closely monitored in such patients for the same reason. Advertising on our site helps support our mission. https://www.nhlbi.nih.gov/health-topics/venous-thromboembolism. About 1 of every 250 Black people in America has the prothrombin gene mutation. Because its an inherited condition, you cant prevent the prothrombin gene mutation. Your brothers and sisters may have inherited the mutated gene for Factor V Leiden, just like you did. xref That's important because high blood pressure can damage blood vessels, increasing blood clot risk. The American Heart Association cites the following as risk factors for blood clots: 5 Symptoms of a Blood Clot You Should Know. Does my factor V Leiden need to be treated? Lockwood CJ, et al. If you or a loved one have factor V Leiden, you might feel scared about what the future will bring. Thick blood: Causes, risk factors, symptoms, and treatment There is no specific treatment for the mutation itself. Want to talk about Multiple Myeloma: Anyone else? The mutation does not cause any symptoms in and of itself. Miscarriages associated with factor V Leiden are more likely to occur later in pregnancy (after the first trimester). Will Eating More Protein Help Your Body Gain Muscle Faster?